Normative modelling (fMRI) project
Project team
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Tim van Balkom1 -
Chris Vriend1 -
Odile van den Heuvel1 -
Ysbrand van der Werf1 -
Andrew Zalesky2 -
Sina Mansour L.3
1Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences, Amsterdam, the Netherlands
2The University of Melbourne department of Biomedical Engineering and Psychiatry
3National University of Singapore Centre for Sleep and Cognition, The University of Melbourne department of Psychiatry
Project summary
The aim of this study is to get a better understanding of the neuranatomical heterogeneity underlying cognitive impairment in PD using normative modelling. Given the involvement of various functional brain circuits in PD-related cognitive impairment that shows high interindividual variety, we aim to develop brain charts of "normal" functional connectivity across the aging lifespan. Using these brain charts, we can compute deviations from normal functional connectivity in a sample of individuals with PD and assess how interindividual variation in deviation from normal connectivity is related to cognitive heterogeneity.
In the future, we aim to use these models to inform treatment protocols that can modulate brain circuit function, e.g. repetitive transcranial magnetic stimulation. Moreover, detailed brain charts based on resting-state functional MRI have not yet been published and may prove highly valuable for other applications in neuropsychiatric disorders and neurological diseases.
Read more about this project in the full secondary proposal PDF.
Link to preregistration: coming soon!
Toolbox used: HALPpipe for fMRI preprocessing; PCNToolkit for normative modelling.